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Related Experiment Videos

Thyrotropin-releasing hormone has multiple actions in cortex.

D J Braitman, C R Auker, D O Carpenter

    Brain Research
    |July 21, 1980
    PubMed
    Summary
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    Thyrotropin-releasing hormone (TRH) directly affects some neurons in the cat sensory motor cortex, exciting or inhibiting them. TRH also modulates acetylcholine responses in specific neuronal populations.

    Area of Science:

    • Neuroscience
    • Neurophysiology
    • Mammalian Cerebral Cortex Research

    Background:

    • Thyrotropin-releasing hormone (TRH) is a hypothalamic peptide hormone.
    • TRH's role in the mammalian cerebral cortex is not fully understood.
    • Investigating TRH's direct and indirect effects on cortical neurons is crucial.

    Purpose of the Study:

    • To examine the direct effects of TRH on identified neurons in the cat sensory motor cortex.
    • To investigate TRH's modulatory effects on acetylcholine (ACh)- and glutamate (Glu)-evoked responses.
    • To determine if TRH acts on discrete neuronal populations within the cortex.

    Main Methods:

    • Electrophysiological recordings were performed on 38 identified neurons in the cat sensory motor cortex.
    • Neurons were classified as pyramidal tract (PT) or nonpyramidal tract (NPT) neurons.

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  • Responses to iontophoretic application of TRH, ACh, and Glu were recorded.

    • Main Results:

    • TRH directly excited two PT neurons and three NPT neurons.
    • TRH directly inhibited two NPT neurons.
    • TRH potentiated ACh-evoked excitation in 4/12 PT neurons and 1/2 unidentified cells, but not on NPT cells.
    • TRH did not potentiate Glu-evoked responses in any tested cells.

    Conclusions:

    • TRH exhibits multiple actions within the mammalian cerebral cortex.
    • TRH's modulatory effects, particularly on ACh responses, are specific to discrete neuronal populations.
    • These findings highlight the complex role of TRH in cortical circuitry.