Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age and beta adrenoceptor-mediated function.

N Dillon, S Chung, J Kelly

    Clinical Pharmacology and Therapeutics
    |June 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Screening for proximal deep vein thrombosis after acute ischemic stroke: a prospective study using clinical factors and plasma D-dimers.

    Journal of thrombosis and haemostasis : JTH·2005
    Same author

    Identification of selenomethionine in selenized yeast using two-dimensional liquid chromatography-mass spectrometry based proteomic analysis.

    The Analyst·2004
    Same author

    Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation.

    The European journal of neuroscience·2004
    Same author

    A follow-up of repair of ruptured uterus in Ethiopia.

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2004
    Same author

    Vesico-vaginal and recto-vaginal fistulae.

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2004
    Same author

    The diagnosis of borderline iron deficiency: results of a therapeutic trial.

    Archives of disease in childhood·2004
    Same journal

    Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Symposium Report: Stakeholders' Perspectives on Phase 1 Trials in Japanese Prior to Multi-Regional Clinical Trials and Future Pathways.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Composite Endpoints in Contemporary Cardiovascular Trials: Trends in Phase 3 Trials and Key Issues in Regulatory Review.

    Clinical pharmacology and therapeutics·2026
    See all related articles

    Older adults show reduced beta-adrenoceptor function. Lymphocyte cyclic adenosine monophosphate (cAMP) production in response to isoproterenol was lower in the elderly, suggesting a generalized decline in these functions with age.

    Area of Science:

    • Pharmacology
    • Gerontology
    • Cellular Biology

    Background:

    • Beta-adrenoceptor (β-AR) responsiveness is crucial for physiological regulation.
    • Age-related changes in β-AR function are not fully understood.
    • Previous studies suggest diminished cardiovascular responses to β-AR agonists in the elderly.

    Purpose of the Study:

    • To compare beta-adrenoceptor-mediated responsiveness between young and old individuals.
    • To investigate age-related alterations in isoproterenol-stimulated cyclic adenosine monophosphate (cAMP) production in lymphocytes.

    Main Methods:

    • Isoproterenol dose-response curves were generated.
    • Lymphocyte cyclic AMP production was measured as an index of β-AR function.
    • Responses were compared between young and elderly subject groups.

    Related Experiment Videos

    Main Results:

    • The elderly group exhibited a rightward shift in the mean log dose-response curve for isoproterenol.
    • The mean maximum response to isoproterenol was significantly lower in older subjects compared to younger subjects.
    • These findings indicate reduced lymphocyte β-AR responsiveness in the elderly.

    Conclusions:

    • The elderly demonstrate a decreased beta-adrenoceptor-mediated response to isoproterenol.
    • This reduced responsiveness, evidenced by lower cyclic AMP production, supports a generalized decline in β-AR functions with aging.
    • The results align with existing evidence of diminished cardiovascular responses in older individuals.