Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lateral horn cells in progressive autonomic failure.

D R Oppenheimer

    Journal of the Neurological Sciences
    |June 1, 1980
    PubMed
    Summary

    Progressive autonomic failure causes severe loss of thoracic spinal cord lateral horn cells. Uncomplicated Parkinson's disease showed no cell loss, while multiple system atrophy without autonomic issues had moderate cell loss.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    AIDS: origin, transmission and moral dilemmas.

    Journal of the Royal Society of Medicine·2010
    Same author

    Oxygen for multiple sclerosis.

    Lancet (London, England)·1983
    Same author

    Congophilic angiopathy of the brain: a clinical and pathological report on two siblings.

    Journal of neurology, neurosurgery, and psychiatry·1982
    Same author

    Distribution of measles antigen and immunoglobulin-containing cells in the CNS in subacute sclerosing panencephalitis (SSPE) and atypical measles encephalitis.

    Journal of the neurological sciences·1982
    Same author

    Laryngeal abductor paralysis in multiple system atrophy. A report on three necropsied cases, with observations on the laryngeal muscles and the nuclei ambigui.

    Brain : a journal of neurology·1981
    Same author

    Ponto-bulbar palsy with deafness (Brown-Vialetto-Van Laere syndrome).

    Journal of the neurological sciences·1981

    Area of Science:

    • Neuroscience
    • Neuropathology
    • Autonomic Nervous System Research

    Background:

    • Progressive autonomic failure is a debilitating neurological condition.
    • The intermediolateral columns of the thoracic spinal cord are crucial for autonomic function.
    • Cell loss in these columns may underlie autonomic dysfunction.

    Purpose of the Study:

    • To quantify neuronal cell loss in the thoracic cord's lateral grey horns in progressive autonomic failure.
    • To compare cell loss in autonomic failure with normal controls, Parkinson's disease, and multiple system atrophy without autonomic symptoms.

    Main Methods:

    • Histological examination and cell counting in the lateral grey horns of the thoracic spinal cord.
    • Comparison of cell counts between 21 cases of progressive autonomic failure, normal controls, Parkinson's disease cases, and multiple system atrophy cases.

    Main Results:

    • Cases with progressive autonomic failure exhibited severe loss of lateral horn cells, averaging a 75% reduction.
    • Uncomplicated Parkinson's disease cases showed no significant difference in cell counts compared to controls.
    • Multiple system atrophy cases without autonomic disturbances demonstrated a moderate loss of approximately 50% of lateral horn cells.

    Conclusions:

    • Severe loss of thoracic spinal cord lateral horn neurons is a hallmark of progressive autonomic failure.
    • Neuronal cell loss in the thoracic cord is more pronounced in autonomic failure than in Parkinson's disease or multiple system atrophy without autonomic symptoms.
    • These findings highlight the specific vulnerability of spinal autonomic pathways in progressive autonomic failure.

    Related Experiment Videos