Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement receptors on normal human lymphocytes containing parallel tubular arrays.

C M Payne, R B Nagle

    The American Journal of Pathology
    |June 1, 1980
    PubMed
    Summary

    Researchers identified complement receptors on lymphocytes with parallel tubular arrays (PTA) using two rosetting techniques. These PTA lymphocytes can bind and phagocytize complement-coated bacteria, confirming their role in immune responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Differences in characteristics of men with localised prostate cancer who demonstrate low, intermediate or high prostate-specific antigen velocity.

    Internal medicine journal·2011
    Same author

    Dose-dependent effects of selenized yeast on total selenium levels in prostatic tissue of men with prostate cancer.

    Nutrition and cancer·2010
    Same author

    Newly recognized syndrome in the neck: 1981 JRSM 74, 814-818.

    Journal of the Royal Society of Medicine·2010
    Same author

    Nephrotoxicity and uptake of 1-benzyl quinolinium in precision-cut rabbit renal cortical slices.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an In Vitro human skin equivalent system: a novel model of human arsenicism.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer.

    British journal of cancer·2007

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Lymphocytes play a crucial role in the immune system.
    • Certain lymphocytes contain unique cytoplasmic inclusions known as parallel tubular arrays (PTA).
    • The functional characteristics of PTA lymphocytes, particularly their surface receptors, require further elucidation.

    Purpose of the Study:

    • To identify and characterize membrane complement receptors on lymphocytes containing parallel tubular arrays (PTA).
    • To investigate the interaction of PTA lymphocytes with complement-coated particles.

    Main Methods:

    • Utilized two rosetting techniques employing complement-coated erythrocytes (EAC rosettes) and complement-coated Salmonella typhi (FBC rosettes).
    • Employed electron microscopy to visualize PTA lymphocytes within rosettes.
    • Differentiated phagocytic cells based on endogenous peroxidase activity.

    Related Experiment Videos

    Main Results:

    • Identified membrane complement receptors on a subpopulation of normal lymphocytes containing PTA.
    • Demonstrated the presence of PTA lymphocytes in both EAC and FBC rosettes via electron microscopy.
    • Observed that PTA lymphocytes interact with complement-coated bacteria, including phagocytosis, and lack monocytic markers.

    Conclusions:

    • PTA lymphocytes possess functional complement receptors.
    • These lymphocytes actively engage with complement-opsonized targets.
    • PTA lymphocytes represent a distinct lymphocytic lineage with specific immune functions.