[Effect of thiol compounds on aniline toxicity and aniline metabolism]

The authors examined systematically the influence of some thiol compounds on the drug metabolism, investigating the effect of potassium ethylxanthogenate, diethyldithiocarbamata, inithiol and penicilamine on the aniline toxicity, methemoglobin formation and aniline-hydroxylase activity. They found that the examined compounds increased aniline toxicity in white male rats. These compounds inhibited aniline-hydroxilase activity. The connection between the increase of the toxicity of aniline under the influence of the examined compounds and their inhibiting action on the metabolism of aniline was discussed.