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Related Experiment Videos

Fine structural alterations in the aging rat pineal gland.

J E Johnson

    Experimental Aging Research
    |April 1, 1980
    PubMed
    Summary

    Aging in rats causes significant changes in the pineal gland, including increased capsule thickness and cellular alterations. These findings highlight age-related structural modifications within the rat pineal gland.

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    Area of Science:

    • Histology
    • Gerontology
    • Neuroscience

    Background:

    • The pineal gland's function is influenced by age-related structural changes.
    • Understanding these changes is crucial for comprehending aging processes in the brain.

    Purpose of the Study:

    • To investigate and document age-related structural alterations in the rat pineal gland.
    • To quantify specific ultrastructural features not previously analyzed.

    Main Methods:

    • Electron microscopy was used to examine pineal glands from rats aged 1 to 28 months.
    • Morphometric and semi-morphometric analyses were performed on cellular structures.

    Main Results:

    • Increased capsule thickness, collagen infiltration, and granular deposits were observed with age.
    • Pinealocytes showed increased nuclear invaginations, inclusions, and larger lipid droplets.
    • Cytoplasmic dense bodies increased in pinealocytes and gliocytes; neuroaxonal dystrophy-like changes were noted.

    Conclusions:

    • The study confirms age-related structural changes in the rat pineal gland.
    • Pinealocyte nuclear inclusions are present, and pineal concretions are suggested.
    • Quantification of several age-related structural features provides new insights.

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