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Ultrastructural changes in granulomatous myopathy.

S Matsubara

    Acta Neuropathologica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Muscle biopsies revealed non-caseating granulomas in women with progressive muscle weakness. These findings suggest granulomatous myopathy may occur even without typical sarcoidosis symptoms.

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    Area of Science:

    • Neurology
    • Pathology
    • Immunology

    Background:

    • Proximal muscle weakness can be debilitating, with diverse underlying causes.
    • Sarcoidosis is a multisystem inflammatory disease often affecting muscles.

    Observation:

    • Muscle biopsies from four women with progressive proximal muscle weakness revealed non-caseating granulomas.
    • Granulomas consisted of epithelioid cells, giant cells, lymphocytes, and macrophages.
    • Muscle fiber damage and regeneration were observed near granulomas, with some fibers infiltrated by inflammatory cells.

    Findings:

    • Non-caseating granulomas were identified in muscle tissue, irrespective of overt clinical sarcoidosis.
    • Histological examination showed inflammatory cell infiltration and degenerative changes in muscle fibers.

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  • Intranuclear inclusions were noted in two of the cases.

    • Implications:

    • This study highlights granulomatous myopathy as a potential diagnosis in cases of unexplained progressive muscle weakness.
    • It expands the understanding of muscle involvement in granulomatous diseases beyond classical sarcoidosis.
    • Further research is warranted to elucidate the specific mechanisms and long-term outcomes of this condition.