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Infection with CDC group DF-2 gram-negative rod: report of two cases
Abstract:
Two patients had bacteremia with Center for Disease Control group DF-2 Gram-negative rods. Previously described patients infected with this organism had clinical syndromes including cellulitis, meningitis, and endocarditis, and generally were severely ill. One of our patients had acute oligoarticular arthritis. The other had fever, headache, malaise, and a generalized rash. In neither case was bacterial infection considered likely at onset, and neither patient received antibiotic therapy. Both patients recovered completely. The organism is a fastidious Gram-negative rod that only recently has been characterized. Methods for isolating and identifying the organism are reviewed. The spectrum and frequency of illnesses caused by this organism are probably greater than previously recognized.
Insights
Two patients recovered from bacteremia caused by a rare Gram-negative rod (DF-2). This finding suggests the spectrum of illnesses associated with this pathogen may be broader than previously understood.
Area of Science:
- Medical Microbiology
- Infectious Diseases
Background:
- Center for Disease Control (CDC) group DF-2 is a fastidious Gram-negative rod.
- Previously documented DF-2 infections typically presented as severe conditions like cellulitis, meningitis, or endocarditis.
Observation:
- Two patients presented with bacteremia due to DF-2.
- One patient exhibited acute oligoarticular arthritis; the other had fever, headache, malaise, and a generalized rash.
- Bacterial infection was not suspected initially in either case, and no antibiotic treatment was administered.
Findings:
- Both patients experienced complete recovery.
- The study reviews methods for isolating and identifying this recently characterized organism.
- DF-2 bacteremia can manifest in diverse clinical presentations beyond severe illness.
Implications:
- The clinical spectrum and incidence of DF-2 infections might be underestimated.
- This highlights the need for increased awareness and diagnostic consideration of DF-2 in various clinical settings.
- Further research is warranted to fully understand the epidemiology and pathogenicity of DF-2.