[Study of the state of blood plasma by the spin probe method]

To evaluate the potentialities of the spin probe method in examination of the blood plasma state, a study was made into the blood plasma bound nitroxyl radical 2,2,4,4-tetramethyl-1,2,3,4-tetrahydro-5,6-benzo-gamma-carbolin-3-oxyl in healthy rabbits and those with pronounced experimental atherosclerosis. The probe absorption by high molecular plasma components was assayed in order to determine the binding constants and concentration of the binding centers, mobility of adsorbed probes and polarity of their surroundings. In the course of experimental atherosclerosis development these parameters underwent changes correlating with those of blood plasma cholesterol level. The data obtained suggest that the spin probe method may be used for assessement of the plasma state for diagnostic and research purposes.