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Updated: Jun 2, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Abstract:
A 27-year-old woman with amenorrhea following cessation of birth control pills was found to have a pituitary tumor which was secreting large amounts of prolactin. Many tumor cells had large mitochondria, the diameter of which ranged between 7 and 12 mu. Some tumor cells also displayed oncocytic transformation, and a few were definite oncocytes. The pathogenesis of mitochondrial swelling in pituitary tumors is discussed and the possible roles of prolonged intake of steroids and/or ischemia are suggested.
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