Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormone precursors.

N Yanaihara

    Clinics in Endocrinology and Metabolism
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Multiple peptide hormone forms exist due to precursor processing. Specific cleavage at arginine or lysine residues generates these diverse hormone variants, impacting biological functions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Harmonising clinical trials within the Gynecologic Cancer InterGroup: consensus and unmet needs from the Fifth Ovarian Cancer Consensus Conference.

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Salmonella ovarian abscess in a patient with rheumatoid arthritis (RA): a case report with literature review.

    Clinical and experimental obstetrics & gynecology·2014
    Same author

    Uterine endometrial carcinoma with trophoblastic differentiation: a case report with literature review.

    European journal of gynaecological oncology·2014
    Same author

    Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer.

    British journal of cancer·2009
    Same author

    Kappa-selective opioid receptor agonists leumorphin and dynorphin inhibit supraoptic neurons in rat hypothalamic slice preparations.

    Journal of neuroendocrinology·2009
    Same author

    Galanin interacts with serotonin in stimulating prolactin secretion in the rat.

    Journal of neuroendocrinology·2009
    Same journal

    Long-term complications of diabetes.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic retinopathy: current concepts of evaluation and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic neuropathies and pain.

    Clinics in endocrinology and metabolism·1986
    Same journal

    The diabetic foot: pathophysiology and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Autonomic neuropathy: its diagnosis and prognosis.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Dialysis: continuous ambulatory peritoneal dialysis and haemodialysis.

    Clinics in endocrinology and metabolism·1986
    See all related articles

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Endocrinology

    Background:

    • Accumulating evidence suggests the existence of multiple molecular forms for various peptide hormones.
    • Understanding peptide hormone heterogeneity is crucial for comprehending their diverse physiological roles.

    Purpose of the Study:

    • To elucidate the biochemical mechanisms responsible for generating multiple peptide hormone forms.
    • To investigate the role of specific proteolytic cleavage events in peptide hormone precursor processing.

    Main Methods:

    • Analysis of peptide hormone precursor sequences.
    • In silico prediction of proteolytic cleavage sites.
    • Review of existing literature on peptide hormone biosynthesis and processing.

    Related Experiment Videos

    Main Results:

    • Identification of specific arginine and lysine residues as key cleavage sites in peptide hormone precursors.
    • Demonstration that differential cleavage at these sites can lead to the generation of distinct peptide hormone isoforms.
    • Correlation between specific cleavage patterns and known multiple hormone forms.

    Conclusions:

    • Proteolytic cleavage of hormone precursors at arginine or lysine residues is a primary mechanism generating multiple peptide hormone forms.
    • This processing pathway contributes significantly to the molecular diversity observed in peptide hormone systems.
    • Further research into these processing events can reveal new insights into hormone regulation and function.