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Related Experiment Videos

Manganese induced testicular changes in monkeys.

R C Murthy, R S Srivastava, S K Gupta

    Experimentelle Pathologie
    |January 1, 1980
    PubMed
    Summary

    Chronic manganese chloride exposure in monkeys caused testicular congestion and weight gain. Histopathology showed seminiferous tubule degeneration, with inhibited enzyme activities, but not as severe as metal-induced encephalopathy.

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    Area of Science:

    • Toxicology
    • Primate Research
    • Reproductive Biology

    Background:

    • Manganese is an essential trace element, but chronic overexposure can lead to toxicity.
    • Understanding the reproductive effects of manganese is crucial for assessing occupational and environmental health risks.

    Purpose of the Study:

    • To investigate the impact of chronic oral manganese chloride administration on primate testicular function.
    • To evaluate histopathological and biochemical changes in the testes following prolonged manganese exposure.

    Main Methods:

    • Monkeys were administered manganese chloride (25 mg/kg b.w. daily) for 18 months.
    • Testicular tissues were examined histopathologically.
    • Enzyme activities (succinic dehydrogenase, glucose-6-phosphate dehydrogenase, acid phosphatase, NADH-diaphorase, alkaline phosphatase) in seminiferous tubules were assayed.

    Main Results:

    • Oral manganese chloride induced testicular congestion and increased testis weight.
    • Histopathology revealed interstitial edema and seminiferous tubule degeneration.
    • Key enzymes like succinic dehydrogenase and glucose-6-phosphate dehydrogenase showed significant inhibition.

    Conclusions:

    • Chronic manganese exposure causes testicular damage in primates.
    • The observed testicular changes are less severe than those seen in manganese-induced encephalopathy.

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