Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The vitamin d hormonal system: implications for bone diseases.

H F DeLuca

    Hospital Practice
    |April 1, 1980
    PubMed
    Summary

    Vitamin D is now understood as a hormone crucial for calcium regulation. Its active form, calcitriol, impacts bone and intestine, showing therapeutic potential for metabolic bone diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Short-term regulation of the renal vitamin D receptor in rats by 1,25-dihydroxycholecalciferol is calcium insensitive.

    The Journal of nutrition·1992
    Same author

    Baculovirus-mediated expression of retinoic acid receptor type gamma in cultured insect cells reveals a difference in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor.

    Proceedings of the National Academy of Sciences of the United States of America·1992
    Same author

    Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

    The Journal of biological chemistry·1992
    Same author

    New concepts of vitamin D functions.

    Annals of the New York Academy of Sciences·1992
    Same author

    Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

    Proceedings of the National Academy of Sciences of the United States of America·1992
    Same author

    A new, highly sensitive assay for 1,25-dihydroxyvitamin D not requiring high-performance liquid chromatography: application of monoclonal antibody against vitamin D receptor to radioreceptor assay.

    Analytical biochemistry·1992

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Metabolic Bone Disease

    Background:

    • Vitamin D was initially classified as a vitamin.
    • Emerging evidence highlights its role as a hormone.

    Purpose of the Study:

    • To elucidate the hormonal functions of vitamin D.
    • To explore the therapeutic applications of vitamin D metabolites in bone diseases.

    Main Methods:

    • Biochemical analysis of vitamin D metabolism.
    • Clinical evaluation of calcitriol in treating bone disorders.

    Main Results:

    • Vitamin D functions as a key hormone in calcium homeostasis.
    • The active metabolite, calcitriol, produced in the kidney, targets bone and intestine.
    • Calcitriol demonstrates efficacy in treating osteodystrophy.

    Conclusions:

    • Vitamin D is a critical hormonal regulator of calcium economy.
    • Calcitriol holds therapeutic promise for various metabolic bone diseases.

    Related Experiment Videos