Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Achondrogenesis type I: light and electron-microscopic studies.

G Molz, M A Spycher

    European Journal of Pediatrics
    |June 1, 1980
    PubMed
    Summary

    Achondrogenesis type I disrupts cartilage development. Key cellular changes include enlarged rough endoplasmic reticulum (RER) filled with material, impacting chondrocytes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypercalcemic-type of small cell carcinoma of the ovary: characterization of a new tumor line.

    Anticancer research·2002
    Same author

    Acquired hair fragility in pili anulati: causal relationship with androgenetic alopecia.

    Dermatology (Basel, Switzerland)·2001
    Same author

    Infantile systemic hyalinosis in siblings: clinical report, biochemical and ultrastructural findings, and review of the literature.

    American journal of medical genetics·2001
    Same author

    [Trichorhinophalangeal syndrome. Case report and biophysical study of hair shaft parameters].

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2001
    Same author

    [How does model- and situation-specific lack of knowledge affect causal inferences?].

    Zeitschrift fur experimentelle Psychologie : Organ der Deutschen Gesellschaft fur Psychologie·2000
    Same author

    Analysis of two bone-prosthesis interfaces and membranes from non-cemented trapeziometacarpal prostheses.

    Annales de chirurgie de la main et du membre superieur : organe officiel des societes de chirurgie de la main = Annals of hand and upper limb surgery·2000

    Area of Science:

    • Cell Biology
    • Developmental Biology
    • Histology

    Background:

    • Achondrogenesis type I is a severe skeletal dysplasia.
    • Understanding chondrocyte ultrastructure is crucial for achondrogenesis research.

    Observation:

    • Light and electron microscopy were used to examine articular and costal cartilage.
    • The study focused on a single case of achondrogenesis type I.

    Findings:

    • Chondrocytes exhibited significant dilatation of the rough endoplasmic reticulum (RER).
    • The dilated RER contained amorphous, electron-opaque material.
    • Hypertrophy of the Golgi apparatus was also observed.
    • The cartilage matrix remained largely unchanged.

    Implications:

    • These ultrastructural findings provide insights into the cellular pathology of achondrogenesis type I.
    • The RER abnormalities suggest a defect in protein processing or secretion.
    • Further research can explore therapeutic targets based on these cellular defects.

    Related Experiment Videos