Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Varicella vaccination: where do we go from here?

P A Brunell

    Hospital Practice
    |September 1, 1980
    PubMed
    Summary

    Further trials for varicella virus in immunocompromised children are warranted despite limited knowledge. Passive immunization offers a safe and effective alternative for managing this severe infection in vulnerable pediatric populations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chickenpox attributable to a vaccine virus contracted from a vaccinee with zoster.

    Pediatrics·2000
    Same author

    Possible role of varicella vaccine in preventing herpes zoster.

    The Pediatric infectious disease journal·1999
    Same author

    Viral gene expression in rat trigeminal ganglia following neonatal infection with varicella-zoster virus.

    Journal of medical virology·1999
    Same author

    Recent advances in varicella-zoster virus infection.

    Annals of internal medicine·1999
    Same author

    Varicella serological status of healthcare workers as a guide to whom to test or immunize.

    Infection control and hospital epidemiology·1999
    Same author

    Lack of evidence of transmission of HIV-1 to family contacts of HIV-1 infected children.

    Clinical pediatrics·1998

    Area of Science:

    • Virology
    • Immunology
    • Pediatrics

    Background:

    • Limited understanding of the varicella virus presents safety concerns.
    • Varicella poses a significant mortality risk in immunocompromised children.

    Purpose of the Study:

    • To evaluate the necessity of further clinical trials for varicella in immunocompromised children.
    • To identify safe and effective management strategies for varicella in this high-risk group.

    Main Methods:

    • Review of existing literature on varicella virus and its effects on immunocompromised children.
    • Analysis of safety and efficacy data for potential therapeutic interventions.

    Main Results:

    • The high mortality rate associated with varicella in immunocompromised children justifies continued research and trials.
    • Passive immunization has demonstrated safety and relative effectiveness as a current management option.

    Conclusions:

    • Despite knowledge gaps, the severe risks of varicella necessitate further investigation in immunocompromised children.
    • Passive immunization is a viable and recommended approach for managing varicella in immunocompromised children pending further trial outcomes.

    Related Experiment Videos