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Identification of Tettnang virus ('possible arbovirus') as mouse hepatitis virus
Intervirology
|January 1, 1980
Abstract:
Virus isolation attempts in specific-pathogen-free suckling mice (strain ICR) yielded 21 virus strains initially shown to be closely related to or identical with Tettnang virus. Subsequent studies showed them, as well as standard strains of Tettnang virus, to be closely related to or identical with mouse hepatitis virus. Tettnang virus is not an arbovirus.
Insights
Researchers identified 21 virus strains from mice, initially thought to be Tettnang virus. Further analysis revealed these strains, and Tettnang virus itself, are identical to mouse hepatitis virus, clarifying Tettnang virus is not an arbovirus.
Area of Science:
- Virology
- Infectious Diseases
- Mouse Models
Background:
- Tettnang virus was initially isolated and characterized.
- Arboviruses are typically transmitted by arthropods.
Purpose of the Study:
- To identify and characterize novel virus strains isolated from specific-pathogen-free mice.
- To determine the precise taxonomic and etiological relationship of Tettnang virus.
Main Methods:
- Virus isolation from suckling mice (ICR strain).
- Comparative analysis of isolated strains with standard Tettnang virus.
- Molecular and serological assays to confirm viral identity.
Main Results:
- 21 virus strains were isolated and initially identified as Tettnang virus.
- Subsequent studies demonstrated these strains are identical to mouse hepatitis virus (MHV).
- Standard Tettnang virus strains were also found to be identical to MHV.
Conclusions:
- Tettnang virus is not a distinct entity but is identical to mouse hepatitis virus.
- Tettnang virus is not an arbovirus, challenging previous classifications.
- This finding clarifies the viral landscape and has implications for mouse health research.