[Control of cell multiplication in vitro. II. Relationship between cell multiplication and cyclic AMP concentration]

Compairing non-transformed mouse fibroblasts and some L-cell variants, it was shown that the decrease of dependence on serum mitogenic factors, and the decease of sensitivity to the contact inhibition of growth do not always correlate with the decrease of intracellular cAMP content. The decrease of sensitivity of transformed cells to the factors limiting non-transformed cell growth in vivo might be also connected with a relative independence of the cell growth on the intracellular level of a cAMP.