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Related Experiment Videos

Eucaryotic transposable genetic elements with inverted terminal repeats.

S Potter, M Truett, M Phillips

    Cell
    |July 1, 1980
    PubMed
    Summary
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    Researchers identified novel transposable genetic elements in Drosophila. These DNA sequences, characterized by inverted repeats, can move within the genome, differing from previously known elements.

    Area of Science:

    • * Molecular Biology
    • * Genetics
    • * Genomics

    Background:

    • * Transposable genetic elements (TEs) are mobile DNA sequences that can alter genome structure and function.
    • * Previous research has identified various TEs in Drosophila, such as copia, but their diversity and mechanisms are still being explored.

    Purpose of the Study:

    • * To investigate the transposition of DNA sequences containing inverted repeats within the Drosophila genome.
    • * To characterize novel transposable genetic elements and compare them to known TEs.

    Main Methods:

    • * Isolation and analysis of five Bam HI DNA segments with inverted repeats from D. melanogaster.
    • * Electron microscopy and restriction mapping for structural analysis.
    • * Southern blot experiments using single-copy flanking sequences to study DNA arrangements in related strains.

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    Main Results:

    • * Three of the isolated sequences were confirmed as transposable genetic elements.
    • * Mobility was demonstrated by purifying DNA segments with and without the inverted repeat sequence.
    • * These elements possess inverted terminal repeats and exhibit a more heterogeneous construction compared to copia.

    Conclusions:

    • * The study identified and confirmed the mobility of novel transposable genetic elements in Drosophila.
    • * These newly discovered elements are distinct from previously described TEs due to their inverted terminal repeats and heterogeneous structure.