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Related Experiment Videos

Penicillamine-associated myasthenia gravis.

J W Albers, R J Hodach, D W Kimmel

    Neurology
    |November 1, 1980
    PubMed
    Summary

    Penicillamine-associated myasthenia gravis (MG) is a distinct syndrome. This condition shows a high remission rate after discontinuing penicillamine, differentiating it from idiopathic myasthenia.

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    Area of Science:

    • Neurology
    • Rheumatology
    • Clinical Immunology

    Background:

    • Penicillamine is a chelating agent used to treat rheumatoid arthritis and Wilson's disease.
    • Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease characterized by fluctuating muscle weakness.
    • Penicillamine-associated MG is a rare but recognized complication of penicillamine therapy.

    Observation:

    • A patient with rheumatoid arthritis developed clinical and electrodiagnostic signs of MG 7 months after starting penicillamine.
    • Electromyography, including single-fiber electromyography, showed abnormalities consistent with MG.
    • The patient's condition improved significantly after discontinuing penicillamine.

    Findings:

    • Clinical improvement correlated with improved electrodiagnostic studies.
    • Serum antibody titers to acetylcholine receptors decreased.
    • Lymphocyte responsiveness to phytohemagglutinin improved after penicillamine withdrawal.

    Implications:

    • Penicillamine-associated MG appears to be a distinct clinical entity.
    • The syndrome is characterized by a favorable prognosis and high remission rate upon drug cessation.
    • Early recognition and discontinuation of penicillamine are crucial for managing this condition.

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