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[Systemic blood diseases in inbred mouse strain CC57W]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|September 1, 1980
Summary
Spontaneous leukemia in CC57W mice significantly increased from 6.8% to 33% between 1969 and 1976. This rise was linked to reticulosarcomatosis and the presence of type C virus particles.
Area of Science:
- Oncology
- Virology
- Hematology
Context:
- CC57W mouse line exhibits a "low cancer" phenotype.
- Spontaneous leukemia incidence was monitored from 1944 to 1976.
Purpose:
- To investigate the significant increase in spontaneous leukemia incidence in the CC57W mouse line.
- To characterize the hematologic and anatomic features of the observed leukemias.
- To identify potential etiological agents, such as viruses, associated with the increased disease frequency.
Summary:
- Spontaneous leukemia rates in CC57W mice rose dramatically from 0.4--6.8% (1944--1969) to 33% (1971--1976).
- Morbid anatomic and hematologic studies identified aleukemic and subleukemic chronic generalized reticulosarcomatosis, primarily affecting the lymphatic system, as the main cause of these blood diseases.
- Electron microscopy detected virus-like type C particles in affected organ cells, suggesting a viral etiology.
Impact:
- Highlights a concerning increase in leukemia incidence in a previously low-cancer mouse model.
- Suggests a potential role for retroviruses in the pathogenesis of spontaneous leukemia.
- Provides a basis for further research into viral oncogenesis and leukemia development in this model system.