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Cyclic nucleotide excretion in human malignancies.

N H Hunt, B Smith, R Pembrey

    Clinical Science (London, England : 1979)
    |June 1, 1980
    PubMed
    Summary
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    Urinary guanosine 3':5'-cyclic monophosphate levels were elevated in patients with lymphoid, myeloid, or melanoma tumors, but not breast or colon cancer. Adenosine 3':5'-cyclic monophosphate levels remained normal across tumor types.

    Area of Science:

    • Oncology
    • Biochemistry
    • Urology

    Background:

    • Cyclic nucleotides, including adenosine 3 ':5 '-cyclic monophosphate (cAMP) and guanosine 3 ':5 '-cyclic monophosphate (cGMP), play crucial roles in cellular signaling.
    • Alterations in cyclic nucleotide metabolism have been implicated in various disease states, including cancer.

    Purpose of the Study:

    • To investigate urinary cyclic nucleotide excretion patterns in cancer patients.
    • To determine if specific tumor types are associated with altered levels of cAMP or cGMP.

    Main Methods:

    • Collected and analyzed 24-hour urine samples from 51 patients diagnosed with malignant tumors and 24 healthy control subjects.
    • Quantified urinary excretion of adenosine 3 ':5 '-cyclic monophosphate and guanosine 3 ':5 '-cyclic monophosphate using established biochemical assays.

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    Main Results:

    • Urinary adenosine 3 ':5 '-cyclic monophosphate (cAMP) excretion was comparable between cancer patients and controls.
    • Significantly elevated urinary guanosine 3 ':5 '-cyclic monophosphate (cGMP) excretion was observed in patients with lymphoid tumors (both sexes), male patients with myeloid tumors, and male patients with malignant melanoma.
    • Normal urinary cGMP excretion was noted in patients with breast carcinoma and colonic adenocarcinoma.

    Conclusions:

    • Urinary cGMP levels may serve as a potential biomarker for certain types of cancer, specifically lymphoid, myeloid, and melanoma.
    • cAMP excretion does not appear to be a reliable indicator in this patient cohort.
    • Further research is warranted to explore the diagnostic and prognostic value of urinary cGMP in oncology.