Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A post-natal decrease in acetylcholine channel open time at rat end-plates.

G D Fischbach, S M Schuetze

    The Journal of Physiology
    |June 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Doxorubicin plus the IGF-1R antibody cixutumumab in soft tissue sarcoma: a phase I study using the TITE-CRM model.

    Annals of oncology : official journal of the European Society for Medical Oncology·2019
    Same author

    Efficacy and tolerability of trabectedin in elderly patients with sarcoma: subgroup analysis from a phase III, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma.

    Annals of oncology : official journal of the European Society for Medical Oncology·2018
    Same author

    Incremental improvement in osteosarcoma chemotherapy?

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Doxorubicin plus the IGF-1R antibody cixutumumab in soft tissue sarcoma: a phase I study using the TITE-CRM model.

    Annals of oncology : official journal of the European Society for Medical Oncology·2015
    Same author

    Future directions for epilepsy research.

    Neurology·2001
    Same author

    Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

    Acetylcholine receptor (AChR) channel open times are longer in neonatal rat skeletal muscle than in adults. These channels mature rapidly after birth, transitioning from slow neonatal to fast adult types.

    Area of Science:

    • Neuroscience
    • Muscle Physiology
    • Molecular Biology

    Background:

    • Acetylcholine receptors (AChRs) mediate neurotransmission at the neuromuscular junction.
    • Understanding AChR channel kinetics is crucial for comprehending muscle function and development.

    Purpose of the Study:

    • To investigate the developmental changes in the mean channel open time (tau) of AChRs in rat skeletal muscle.
    • To compare channel kinetics between neonatal and adult neuromuscular junctions.

    Main Methods:

    • Analysis of acetylcholine (ACh) current fluctuations to estimate mean channel open time (tau).
    • Measurement of time constants for miniature end-plate current decays (taus).
    • Comparison of kinetic parameters at adult end-plates, neonatal end-plates, and in cultured myotubes.

    Related Experiment Videos

    Main Results:

    • Adult rat end-plates exhibited a mean channel open time (tau) of 1.4 msec at 21°C, with similarly brief miniature end-plate current decay times (taus).
    • Neonatal rat end-plates showed significantly longer tau and taus (4.5 msec at 21°C), comparable to embryonic myotubes and denervated adult fibers.
    • Both tau and taus decreased to adult values within the first two weeks postpartum, with evidence of mixed channel populations during this transition.

    Conclusions:

    • ACh receptor channel kinetics mature significantly during the early postnatal period in rat skeletal muscle.
    • The transition involves a shift from slower, neonatal-type channels to faster, adult-type channels.
    • End-plates in transition may co-express both channel types, contributing to complex kinetic profiles.