Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental studies on TDI dermatitis in mice.

K Yasuda, G Nozawa, T Goto

    The Journal of Toxicological Sciences
    |February 1, 1980
    PubMed
    Summary

    Allergic contact dermatitis was induced by 2,4-toluene diisocyanate (TDI) in mice. T cells appear essential for this TDI contact sensitivity, as it was not observed in nude mice.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Global precedence, spatial frequency channels, and the statistics of natural images.

    Journal of cognitive neuroscience·2013
    Same author

    Differences in the luminance of the first and second displays affects visible persistence in opposite ways.

    Vision research·1998
    Same author

    Fate of neglected targets: a chronometric analysis of redundant target effects in the bisected brain.

    Journal of experimental psychology. Human perception and performance·1995
    Same author

    Visual-auditory interactions in sensorimotor processing: saccades versus manual responses.

    Journal of experimental psychology. Human perception and performance·1994
    Same author

    Parallel and serial processes in the human oculomotor system: bimodal integration and express saccades.

    Biological cybernetics·1994
    Same author

    Increased oxidized form of human serum albumin in patients with diabetes mellitus.

    Diabetes research and clinical practice·1992

    Area of Science:

    • Immunology
    • Toxicology
    • Dermatology

    Background:

    • 2,4-toluene diisocyanate (TDI) is a chemical known to cause allergic reactions.
    • Contact dermatitis is a common immune response to various environmental triggers.

    Purpose of the Study:

    • To investigate the role of T cells in the development of allergic contact dermatitis induced by TDI.
    • To characterize the immune response to TDI in a murine model.

    Main Methods:

    • BALB/c mice were sensitized with 5% TDI and challenged with 1% TDI in olive oil.
    • Ear thickness was measured to assess swelling as an indicator of dermatitis.
    • Experiments were also conducted on BALB/c-nu/nu (nude) mice to evaluate T cell-dependent responses.

    Main Results:

    • Sensitized mice showed a significantly higher ear swelling rate (more than double) compared to unsensitized mice 48 hours post-challenge.
    • Delayed type hypersensitivity to TDI could not be induced in nude mice, even with a 30% TDI solution.

    Conclusions:

    • T cells play a critical role in mediating contact sensitivity to TDI in BALB/c mice.
    • The findings highlight the T cell-dependent nature of TDI-induced allergic contact dermatitis.

    Related Experiment Videos