Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Subcutaneous crystal deposition in pseudogout.

B M Rothschild, M J Round

|November 7, 1980

Summary

Diagnosing gout requires identifying crystals. This study found calcium pyrophosphate crystals in patients suspected of gout, highlighting the importance of soft-tissue aspiration when joint fluid analysis is inconclusive.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Congenital malformations of the vertebral column in ancient amphibians.

Anatomia, histologia, embryologia·2013

Same author

Adaptations for marine habitat and the effect of Triassic and Jurassic predator pressure on development of decompression syndrome in ichthyosaurs.

Die Naturwissenschaften·2012

Same author

Do ribs actually have a bare area? A new analysis.

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2011

Same author

Two faces of "rheumatoid arthritis": type a versus type B disease.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008

Same author

Comparative frequency of osseous macroscopic pathology and first report of gout in captive and wild-caught ratites.

Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2007

Same author

Skeletal manifestations of leprosy: analysis of 137 patients from different clinical settings in the pre- and post-modern treatment eras.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2006

Area of Science:

Rheumatology
Crystal-Induced Arthropathies

Background:

Gout is often suspected based on clinical presentation.
Distinguishing between different crystal arthropathies is crucial for accurate diagnosis and treatment.
Uric acid crystals are the hallmark of gout, but other crystals can mimic its symptoms.

Purpose of the Study:

To investigate the diagnostic utility of soft-tissue aspiration in patients with suspected gout.
To identify the types of crystals present in inflamed periarticular tissues.
To evaluate the role of soft-tissue aspiration when standard arthrocentesis is unsuccessful.

Main Methods:

Aspiration of inflamed periarticular tissues from seven patients with suspected gout.
Microscopic examination of aspirates for positively birefringent crystals.
Radiologic assessment for chondrocalcinosis.
Clinical correlation and exclusion of uric acid crystals.

Main Results:

Positively birefringent calcium pyrophosphate crystals were identified in all seven patients.
Chondrocalcinosis was observed radiologically.
Uric acid crystals were not identified in any of the patients.
Inflamed periarticular tissues and surrounding soft tissues contained calcium pyrophosphate crystals.

Conclusions:

Soft-tissue aspiration is a valuable diagnostic tool for identifying calcium pyrophosphate crystals in suspected gout cases.
Crystal identification in periarticular tissues is important, especially when arthrocentesis is unsuccessful.
This method aids in differentiating gout from other crystal-induced arthropathies.

Related Experiment Videos