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Unifected avian cells contain structurally unrelated progenitors of viral sarcoma genes
Abstract:
A single gene, src of Rous sarcoma virus (RSV) coding for a protein of pp60src, is responsible for the transformation of fibroblasts. DNA sequences homologous to src (the endogenous sarc) are presented in uninfected cells of chickens and other vertebrates. Endogenous nucleotide sequences have also been found in the putative transforming genes of MC29 (ref. 6) and avian erythroblastosis virus. These viruses, however, induce different spectra of tumours in animals. From analysis of a new avian sarcoma virus, Y73, we present here evidence suggesting that multiforms of viral sarcoma genes originated from cellular genetic sequences, and that these viral genes are structurally unrelated, but have similar pathogenicities.
Insights
Viral sarcoma genes, like Rous sarcoma virus (RSV) src, originate from cellular DNA sequences. Analysis of avian sarcoma virus Y73 suggests these viral genes are structurally diverse yet share similar disease-causing abilities.
Area of Science:
- Oncology
- Molecular Biology
- Virology
Background:
- The Rous sarcoma virus (RSV) src gene encodes pp60src, a protein driving fibroblast transformation.
- Cellular DNA sequences homologous to src, termed endogenous sarc, are present in various vertebrate species.
- Related nucleotide sequences are found in oncogenes of other avian viruses like MC29 and avian erythroblastosis virus, which cause distinct tumors.