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Related Experiment Videos

Do human platelets have opiate receptors?

A Reches, A Eldor, Z Vogel

    Nature
    |November 27, 1980
    PubMed
    Summary
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    This study investigated the effect of opiates on human platelets, finding no evidence that opiates affect platelet aggregation or possess opiate receptors. These findings challenge previous hypotheses linking opiate mechanisms to platelet activity.

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Neuroscience

    Background:

    • Previous studies suggested opiates inhibit prostaglandin E1 (PGE1)-sensitive adenylate cyclase (AC), potentially explaining analgesic effects.
    • This hypothesis was supported by neuroblastoma x glioma hybrid cells but contradicted by studies on mammalian brain tissue.
    • PGE1 inhibits platelet aggregation via AC activation; some research indicated morphine interferes with this process.

    Purpose of the Study:

    • To reproduce findings suggesting morphine inhibits PGE1's anti-aggregating effect on platelets via AC.
    • To examine morphine's impact on PGE1-sensitive AC activity in platelet lysates and cyclic AMP accumulation in intact platelets.
    • To assess the presence of opiate receptors in human platelets using 3H-etorphine binding studies.

    Main Methods:

    Related Experiment Videos

    • Attempted to replicate Gryglewski et al.'s findings on opiate effects on platelet aggregation.
    • Assessed the influence of morphine on prostaglandin E1 (PGE1)-sensitive adenylate cyclase (AC) activity in platelet lysates.
    • Investigated PGE1-induced cyclic AMP accumulation in intact human platelets.
    • Conducted direct binding studies using 3H-etorphine to detect opiate receptors in platelets.

    Main Results:

    • Opiates did not affect human platelet aggregation in this study, contrary to previous reports.
    • No evidence was found for the presence of opiate receptors in human platelets.
    • Morphine did not inhibit PGE1-sensitive AC activity or PGE1-induced cyclic AMP accumulation in platelets.

    Conclusions:

    • The presence of opiate receptors in human platelets is unlikely.
    • The proposed mechanism of opiate action via inhibition of platelet AC is not supported by these findings.
    • These results suggest that opiate effects are not mediated through human platelets.