[Hormonal regulation of heparin clearance in immobilization stress in rats]

Intensity of heparin (H) clearance is reduced and the latter gets retained in the blood flow in rats subjected to immobilization stress. A stable fall is seen when immobilization is continued not less than 20 minutes. A decrease in the rate of H secretion from the blood flow is associated with ACTH concentration in the blood. Immobilization stress does not affect the intensity of H clearance in the animals with ACTH-release blocked by DOCA administration. ACTH use was conducive to a further decrease in H clearance intensity in animals exposed to immobilization. The rate of H secretion from the blood flow in this case is minimum and significantly differs from the rate of H clearance in animals immobilized without ACTH administration.