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[Histamine-type reactions seen in general anesthesia].

H Vignon

    Annales De L'Anesthesiologie Francaise
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Anesthetic agents can trigger histamine release, leading to serious adverse events like cardiac arrest. While complex factors contribute, managing histamine levels is key, with treatments proving effective in most cases.

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    [Comparative study of nitrogen sparing during parenteral feeding as a function of carbohydrate intake].

    Annales de l'anesthesiologie francaise·1977

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Toxicology

    Context:

    • Adverse events during anesthesia are a significant concern.
    • Histamine release is a known potential side effect of certain anesthetic agents.
    • Understanding the mechanisms behind these reactions is crucial for patient safety.

    Purpose:

    • To analyze the incidence and characteristics of histaminic-type accidents following anesthetic administration.
    • To investigate the relationship between histamine levels and the severity of adverse events.
    • To evaluate the effectiveness of current treatment protocols for these reactions.

    Summary:

    • A study across 7 Anesthesia and Reanimation departments examined adverse events linked to anesthetic agents.
    • Most agents have histamine-releasing properties; observed accidents, though potentially multifactorial (serotonin, bradykinin), correlate with histamine levels.

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  • Cardiac arrests were investigated in relation to these reactions, with treatment showing high efficacy (1 death in 66 cases).

    • Impact:

    • Highlights the critical role of histamine in anesthetic-related adverse events.
    • Suggests a need for careful monitoring of histamine levels during anesthesia.
    • Demonstrates the effectiveness of current treatment strategies, improving patient outcomes.