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Isolation of parainfluenza virus type 3 from an infant with meningoencephalitis
Virologie
|July 1, 1980
Abstract:
A parainfluenza virus type 3 strain was isolated from the cerebrospinal fluid of an infant with a clinical diagnosis of meningoencephalitis. Specific HAI antibodies to parainfluenza virus type 3, ranging in titer from 1/80 to 1/160 could be detected in the infant's serum. A 2-fold rise in the level of complement fixing serum antibodies-from 1/16 at the first to 1/32 at the second collection-was recorded.
Insights
Parainfluenza virus type 3 was identified in an infant diagnosed with meningoencephalitis. Antibody levels in the infant
Area of Science:
- Virology
- Immunology
- Pediatric Neurology
Background:
- Meningoencephalitis in infants can have various etiologies.
- Parainfluenza virus type 3 (PIV3) is a known respiratory pathogen.
- Cerebrospinal fluid (CSF) analysis is crucial for diagnosing central nervous system infections.
Observation:
- A PIV3 strain was successfully isolated from the CSF of an infant presenting with meningoencephalitis.
- The infant's serum demonstrated the presence of specific hemagglutination inhibition (HAI) antibodies against PIV3.
- Antibody titers ranged from 1/80 to 1/160, indicating an immune response.
Findings:
- A significant 2-fold increase in complement-fixing serum antibodies against PIV3 was observed.
- Antibody levels rose from 1/16 in the initial sample to 1/32 in the subsequent sample.
- These serological findings correlate with the viral isolation from CSF.
Implications:
- This case highlights PIV3 as a potential causative agent of meningoencephalitis in infants.
- Early identification and diagnosis of PIV3-associated neurological disease are critical.
- Further research into PIV3 neurovirulence and pathogenesis is warranted.