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Updated: Aug 13, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Increased feeding and hyperglycemia elicited by intracerebroventricular 5-thioglucose
Abstract:
5-Thioglucose (5-TG) is a glucose analogue in which sulfur is substituted for the pyranose ring oxygen. Intracerebroventricular infusion of 5-TG caused prompt initiation of feeding and a marked rise in plasma glucose concentration at doses as low as 0.54 mumol (106 microgram). 5-TG is, therefore, more potent for eliciting feeding than any other previously tested glucose antimetabolite. The potency of 5-TG for eliciting feeding should make 5-TG a useful tool for localizing brain glucoreceptors which participate in the control of food intake.
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