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[Biochemical and pharmacological approach to the functional disorders observed in demyelination mutants (GABAergic
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1980
Abstract:
The abnormal behavior observed in diseases of myelin remains unexplained. Mutations in the mouse in which the main phenotypic expression involves myelination is a useful tool. As tonic seizures are observed, an electrophysiological, pharmacological and biochemical study was performed. The convulsions seem to be linked mainly to an alteration of the alpha-adrenergic system. The GABA-ergic system is also modified. The relations between these observations and the defect of myelination remain to be elucidated.