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Production of Replication-Defective Retrovirus by Transient Transfection of 293T cells
09:40

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Published on: December 3, 2007

[Mechanism(s) of neoplastic transformation by avian oncogenic retroviruses]

P Vigier, J M Biquard, C Krycève-Martinerie

    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1980
    PubMed

    Insights

    Avian oncogenic retroviruses cause neoplastic transformation through oncogene expression. A cellular proteic factor, activated by the oncogene, maintains morphological transformation in virally infected cells.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Virology

    Context:

    • Avian oncogenic retroviruses, particularly sarcoma viruses, induce neoplastic transformation.
    • Transformation is mediated by viral oncogenes, which are likely derived from cellular genes.
    • The viral oncogene's protein product targets cellular components, altering cell characteristics.

    Purpose:

    • To investigate the molecular mechanisms underlying neoplastic transformation induced by avian oncogenic retroviruses.
    • To identify cellular factors involved in maintaining the transformed phenotype.

    Summary:

    • Neoplastic transformation by avian oncogenic retroviruses results from the expression of viral oncogenes.
    • The oncogene protein affects various cellular targets, leading to altered cell behavior.
    • A cellular proteic factor, derepressed or activated by oncogene expression, is crucial for maintaining morphological transformation.
    • This factor is also present in cells transformed by other oncogenic agents, suggesting a common pathway.

    Impact:

    • Elucidates the role of viral oncogenes and cellular factors in cancer development.
    • Provides insights into the common mechanisms of transformation across different oncogenic agents.
    • Potential implications for understanding and targeting cancer progression.

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