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Phase I clinical studies with WR-2721.

M M Kligerman, M T Shaw, M Slavik

    Cancer Clinical Trials
    |January 1, 1980
    PubMed
    Summary

    Toxicity studies of S-2-(3 aminopropylamino)-ethylphosphorothioic acid (WR-2721) show it is safe for patients in remission after radiation therapy. Further tests will assess potential cardiac or vascular effects before combining WR-2721 with radiotherapy.

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    Area of Science:

    • Oncology
    • Radiotherapy
    • Pharmacology

    Background:

    • S-2-(3 aminopropylamino)-ethylphosphorothioic acid (WR-2721) is being investigated for its radioprotective properties.
    • Patients in remission post-radiation therapy are candidates for toxicity studies.

    Purpose of the Study:

    • To assess the toxicity profile of WR-2721 in patients undergoing radiation therapy.
    • To determine the safety of escalating WR-2721 dosage.
    • To evaluate the potential for combining WR-2721 with conventional radiotherapy.

    Main Methods:

    • Dose escalation of WR-2721 from 25 to 250 mg/m2.
    • Monitoring patients for adverse symptoms, including blood pressure variations.
    • Planned cardiac toxicity and peripheral vascular reaction tests.

    Main Results:

    • WR-2721 was administered at doses up to 250 mg/m2 without significant adverse symptoms.
    • Minor, asymptomatic systolic blood pressure variations (8-10 points) were observed in some patients.
    • Animal studies indicate potential for normal tissue protection without compromising tumor efficacy.

    Conclusions:

    • WR-2721 demonstrates a favorable safety profile at tested doses in patients post-radiation therapy.
    • Further investigation is warranted to rule out cardiac and vascular effects.
    • Combining WR-2721 with radiotherapy is a potential strategy for enhancing treatment efficacy and reducing side effects.

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