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[The glucagon syndrome].

G Goldinger, P Aeberhard

Helvetica Chirurgica Acta

|June 1, 1980

Summary

This summary is machine-generated.

Glucagonoma syndrome, characterized by a specific skin rash, is a potentially curable condition. Surgical resection of glucagon-secreting pancreatic tumors can lead to apparent cure, with rapid improvement of skin manifestations.

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Area of Science:

Endocrinology
Surgical Oncology

Background:

Glucagonoma syndrome, associated with glucagon-secreting pancreatic tumors, was not well-defined until the 1970s.
Early reports described features like necrolytic migratory erythema, weight loss, and anemia.

Observation:

The study presents two cases of glucagonoma, one in the pancreatic tail and another in the pancreatic corpus.
Patients experienced significant improvement in skin rash post-tumor resection.

Findings:

Necrolytic migratory erythema is a key symptom of glucagonoma syndrome.
Surgical extirpation of pancreatic glucagonomas can result in a cure, as demonstrated by rapid symptom resolution.

Implications:

Early diagnosis and surgical intervention are crucial for managing glucagonoma syndrome.

Complete tumor resection offers a favorable prognosis and potential cure for affected patients.