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Related Experiment Videos

Morphologic probes of polypeptide hormone receptor interactions.

P Gorden, J L Carpentier, P Freychet

    The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
    |August 1, 1980
    PubMed
    Summary

    Cell surface receptors bind polypeptide hormones and growth factors, which are then internalized and degraded by lysosomes. This process links hormone degradation with receptor regulation.

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    Area of Science:

    • Cell Biology
    • Molecular Endocrinology

    Background:

    • Cell surface receptors bind various ligands, including polypeptide hormones and growth factors.
    • These ligand-receptor complexes are internalized by cells at physiological temperatures.

    Purpose of the Study:

    • To elucidate the intracellular fate of ligand-receptor complexes.
    • To understand the relationship between ligand internalization and receptor regulation.

    Main Methods:

    • Investigated the internalization of naturally occurring ligands by cells.
    • Examined the intracellular association of internalized ligands with lysosomes.

    Main Results:

    • Ligands, such as polypeptide hormones and growth factors, bind to specific cell surface receptors.

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  • Internalized ligands associate with lysosomes within the cell.
  • Receptor-mediated internalization facilitates the degradation of both the ligand and potentially the receptor.

    • Conclusions:

    • Receptor-mediated internalization is a key mechanism for cellular processing of ligands.
    • This process couples ligand degradation with receptor regulation, influencing cellular signaling pathways.