[Variations of 3' 5' cyclic AMP level in CSF after SAH with or without vasospasm (author's transl)]

Levels of 3' 5' AMPc in CSF were analysed by radioimmunoassay in 56 patients. 12 were used as control and 33 had a Subarachnoid Haemorrage (SAH) between 1 and 22 days before sampling. Out of these 33 cases, 20 had an arterial aneurysm, 7 showed a more or less relevant degree of vasospasm on arteriography. 11 other patients presenting different neurological diseases were studied for comparison. (Ischemia, Hydrocephalus, Atrophy, Hematoma). 3' 5' AMPc level in CSF was found to be very low in case of SAH, especially in patients harboring a definite vasospasm. The significance of AMPc level in CSF is discussed in relation with impairment of consciousness, spasm, ischemia, cortical atrophy, hydrocephalus and hematoma.