Related Experiment Video
Updated: Jul 28, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
Erythrocyte membrane cation carrier in manic-depressive psychosis
Abstract:
Erythrocyte Na-K ATPase and sodium pump site numbers were estimated in groups of depressed, manic and recovered patients. The activity of Na-K ATPase per pump site was lower in the depressed group than in the recovered group. In the manic group Na-K ATPase was lower than that of the recovered group, whereas there was no difference in the pump site numbers. In the more severe manics the activity of Na-K ATPase per pump site was significantly lower than that of the recovered patients. Therefore, the change occurring in the erythrocyte membrane cation carrier in manic-depressive psychosis is probably in the activity of individual Na-K ATPase molecules and not in the number of Na-K ATPase molecules per cell.
Related Concept Videos
G-protein Coupled Receptors
Drugs Affecting Neurotransmitter Release or Uptake
Psychosis and Antipsychotic Drugs: Overview
Psychosis: Goals of Pharmacotherapy
Mania and Antimanic Drugs: Overview
Depression: Overview

