Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tamoxifen and hypercalcaemia. A case report.

W R Bezwoda, D Derman, M Zaltzman

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |November 15, 1980
    PubMed
    Summary

    Tamoxifen (Nolvadex) therapy may cause hypercalcemia in breast cancer patients. This condition resolved upon drug withdrawal and recurred upon reintroduction, suggesting a causal link.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functioning, health-related quality of life and satisfaction of adults who required an amputation because of unrelenting complex regional pain syndrome type i; a scoping review using the international classification of functioning as a framework.

    Disability and rehabilitation·2026
    Same author

    The effects of amputation on functioning, satisfaction and health-related quality of life of adults with brachial plexus injury; a scoping review.

    Disability and rehabilitation·2026
    Same author

    Multi-institutional virtual peer review for reirradiation: dedicated workflow and one-year results.

    Technical innovations & patient support in radiation oncology·2025
    Same author

    Computed tomography for evaluation of abdominal wall hernias-what is the value of the Valsalva maneuver?

    Hernia : the journal of hernias and abdominal wall surgery·2024
    Same author

    Characteristics and special challenges of neonatal emergency transports.

    Early human development·2024
    Same author

    Model-based subcutaneous insulin for glycemic control of pre-term infants in the neonatal intensive care unit.

    Computers in biology and medicine·2023

    Area of Science:

    • Oncology
    • Endocrinology

    Background:

    • Tamoxifen is a widely used adjuvant hormonal therapy for breast carcinoma.
    • Hypercalcemia is a potential complication in cancer patients, particularly those with bone metastases.

    Observation:

    • A patient receiving tamoxifen (Nolvadex) for adjuvant hormonal therapy developed hypercalcemia.
    • The patient's serum calcium levels normalized after discontinuing tamoxifen.
    • Hypercalcemia recurred upon rechallenge with tamoxifen, strengthening the association.

    Findings:

    • The observed hypercalcemia in this patient is likely causally related to tamoxifen therapy.
    • This case highlights a potential adverse effect of tamoxifen that requires clinical monitoring.
    • Mechanisms underlying tamoxifen-induced hypercalcemia in breast cancer warrant further investigation.

    Implications:

    • Clinicians should be vigilant for hypercalcemia in patients treated with tamoxifen.
    • Understanding the mechanisms may lead to better management strategies for tamoxifen-related side effects.
    • This case contributes to the literature on drug-induced hypercalcemia in oncology.

    Related Experiment Videos