Control of sv40 replication by a simple chromosome in monkey-hamster cell hybrids

Somatic cell hybrids produced between cercopithecoid monkey and Chinese hamster cells were used to assay susceptibility to SV40 viral infection in an attempt to define the primate factors that determine permissiveness to viral replication. These cell hybrids, which differed in their primate chromosome complement, were found to differ also in their ability to sustain viral replication. A correlation was found between an elevated SV40 viral replication and the presence of the chromosomes 11 in the rhesus monkey and 12 in the African green monkey which seem to be homologous to human 11. Preliminary studies also showed that the same chromosome seems to be responsible for the ability of the cell hybrids to rescue virus from rodent-transformed cells.