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Pregnancy specific beta-1 glycoprotein (SP1) in patients with trophoblastic disease: molecular heterogeneity and a
Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
|August 1, 1980
Abstract:
The reactivity of sera from 19 patients with trophoblastic disease was analyzed in analytic immunoelectrophoresis using rabbit and human pregnancy specific beta-1 glycoprotein (SP1) antisera. Molecular heterogeneity of SP1 was demonstrated in crossed immunoelectrophoresis and a "SP1 consuming factors" was found in serum from a patient with choriocarcinoma. The "SP1 consuming factor" was precipitated by 1.65 M (NH4)2SO4. The results are discussed in relation to quantification of circulating SP1 patients with trophoblastic disease.