[Lung-converting-enzyme as a possible cell-maker in connection with the ultrastructural morphology in...

The lung shock syndrome, associated with a high rate of mortality, has been tested on an experimental animal model and was compared with clinical results. Consequently we obtained specimens as a base for morphologic examinations and LCE-determinations. A modified flurometric method to determine the angiotensin-converting-enzyme (LCE) has been developed. As a consequence a significant increase of the LCE-activity in shock also was noticed which might have been caused by the damage of the endothelial cells. The main part of this enzyme is situated on the surface of the lung endothelial cells and could be used as a marker enzyme.