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Related Experiment Videos

Adrenal gland function in dogs given methylprednisolone.

K B Spencer, F N Thompson, T Clekis

    American Journal of Veterinary Research
    |September 1, 1980
    PubMed
    Summary

    Methylprednisolone (MP) and methylprednisolone acetate (MPA) affect canine serum cortisol levels. MPA severely suppresses cortisol and adrenal response, while daily MP also depresses adrenal function compared to alternate-day dosing.

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    Area of Science:

    • Veterinary Pharmacology
    • Endocrinology

    Background:

    • Corticosteroids like methylprednisolone are widely used in veterinary medicine.
    • Understanding their impact on the hypothalamic-pituitary-adrenal (HPA) axis is crucial for safe and effective treatment.

    Purpose of the Study:

    • To evaluate the effects of orally administered methylprednisolone (MP) and intramuscular methylprednisolone acetate (MPA) on serum cortisol levels and adrenal gland responsiveness in dogs.
    • To compare the impact of daily versus alternate-day oral MP administration.

    Main Methods:

    • Serum cortisol was measured by radioimmunoassay in dogs over a 9-week period.
    • Dogs received oral MP (daily or alternate-day) or intramuscular MPA (weekly).
    • Adrenal gland response to ACTH stimulation was assessed at specific intervals post-treatment.

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    Main Results:

    • Both daily and alternate-day oral MP caused a slight but significant decrease in resting cortisol.
    • Weekly MPA administration resulted in severe suppression of resting cortisol.
    • MPA rendered adrenal cortices unresponsive to ACTH stimulation.
    • Daily MP administration depressed the ACTH response, unlike alternate-day MP.

    Conclusions:

    • Alternate-day oral MP administration allows for a preserved adrenal response to ACTH.
    • Daily oral MP partially suppresses adrenal function.
    • Intramuscular MPA causes profound and prolonged adrenal suppression in dogs.