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[Humoral immunity and blastic transformation of lymphocytes in trisomy 21]
Studies of immunologic parameters in 52 children with trisomy 21 revealed that -the changes in serum immunoglobulin patterns were minimal, although some delay in the age-dependent rise of IgG concentration was observed; -lymphocyte reactivity to phytohemagglutinin showed a shift with maximal 3H-thymidine incorporation at low PHA concentration; -presence of HBs antigen at an increased incidence, possible existence of anti-thyroid antibodies in serum of trisomy patients and also in that of their parents, abnormalities in phagocytosis, illustrate that trisomy 21 can be associated with multiple immunologic dysfunctions.
Studies of immunologic parameters in 52 children with trisomy 21 revealed that -the changes in serum immunoglobulin patterns were minimal, although some delay in the age-dependent rise of IgG concentration was observed; -lymphocyte reactivity to phytohemagglutinin showed a shift with maximal 3H-thymidine incorporation at low PHA concentration; -presence of HBs antigen at an increased incidence, possible existence of anti-thyroid antibodies in serum of trisomy patients and also in that of their parents, abnormalities in phagocytosis, illustrate that trisomy 21 can be associated with multiple immunologic dysfunctions.