Related Experiment Video
Updated: Aug 22, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
Estimation of effective parabronchial gas volume during intermittent ventilatory flow: theory and application in the
Abstract:
The difference in gas exchange performance between continuous and intermittent ventilatory flow is theoretically studied in the alveolar lung model. When measurements obtained with intermittent flow are analyzed assuming continuous flow, an apparent diffusing capacity. Dapp, results which is an underestimate of the true value, D. This true value, D, may be assessed from measurements at continuous flow. With decreasing effective lung gas volume, Veff, Dapp increasingly deviates D. The dependence of Dapp/D on Veff in the parabronchial lung seems to be similar to that in the alveolar lung. Experimental data of Dapp/D (Scheid et al., 1977) are used to assess Veff for the duck lung. The average value of Veff thus obtained, 93 ml, exceeds the anatomical estimate of parabronchial gas volume. Gas transfer across the open parabronchial ends may contribute in enlarging the parabronchial gas volume to the volume, Veff, that is effective as gas capacity in conditions of non-steady ventilatory flow.
More Related Videos
Related Concept Videos
Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
Respiratory Volumes
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Pressure Relationships in Thoracic Cavity
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Pulmonary Ventilation: Inhalation
Boyle's law becomes particularly pertinent when examining respiratory...
Respiratory Volumes and Capacities
Application of Integration: Problem Solving

