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Related Experiment Videos

Poxvirus and multiple tumors in an eastern gray squirrel.

D J O'Connor, R W Diters, S W Nielsen

    Journal of the American Veterinary Medical Association
    |November 1, 1980
    PubMed
    Summary

    A gray squirrel presented with skin tumors and lung nodules. Histopathology revealed widespread fibromas and adenomas, with poxvirus inclusion bodies found in tumors.

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    Area of Science:

    • Veterinary Pathology
    • Wildlife Diseases
    • Oncology

    Background:

    • Gray squirrels (Sciurus carolinensis) are common urban wildlife.
    • Tumors in wildlife can have significant population impacts.
    • Poxviruses are known to cause proliferative lesions in various species.

    Observation:

    • A juvenile gray squirrel exhibited numerous skin fibromas and was in poor health.
    • Necropsy identified multiple firm white nodules in the lungs.
    • Histological examination revealed fibromatous proliferations in the skin, alimentary tract, lymph node, and myocardium.

    Findings:

    • The lung nodules were identified as bronchoalveolar adenomas.
    • Tubular adenomas were present in the renal cortex.
    • Eosinophilic intracytoplasmic poxvirus inclusion bodies were observed in both mesenchymal and epithelial tumors, indicating a viral etiology.

    Implications:

    • This case highlights the potential for poxvirus to induce diverse neoplastic and proliferative lesions in gray squirrels.
    • Understanding the oncogenic potential of poxviruses in wildlife is crucial for disease surveillance.
    • Further research is needed to characterize the specific poxvirus and its transmission dynamics in squirrel populations.

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