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Gene expression of Abelson murine leukemia virus
Progress in Clinical and Biological Research
|January 1, 1980
Summary
Abelson murine leukemia virus (A-MuLV) uses a protein (P120) to transform lymphoid cells. Researchers developed serological reagents to identify P120, potentially revealing its cellular origin in normal mouse tissues.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Abelson murine leukemia virus (A-MuLV) is a simple genetic system for studying lymphoid cell transformation.
- A-MuLV encodes a 120,000 molecular weight protein (P120), with a cell surface-expressed portion of unknown function.
Purpose of the Study:
- To investigate the function of the cell surface-expressed portion of P120.
- To identify the cellular gene from which A-MuLV was derived.
Main Methods:
- Production of serological reagents specific for P120 in mice with regressing A-MuLV syngeneic tumors.
- Utilizing these sera to identify P120 in normal mouse lymphoid tissues.
Main Results:
- Successfully produced serological reagents specific for P120.
- These reagents identified a protein in normal mouse lymphoid tissues.
Conclusions:
- The identified protein in normal lymphoid tissues may represent the cellular proto-oncogene from which A-MuLV originated.
- Further research is needed to elucidate the function of P120 and its cellular homolog.