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Related Experiment Videos

Myofibroblasts in soft tissue sarcomas.

R Lagacé, W Schürch, T A Seemayer

    Virchows Archiv. A, Pathological Anatomy and Histology
    |January 1, 1980
    PubMed
    Summary
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    Abundant myofibroblasts in soft tissue lesions suggest a benign process, not cancer. These cells, common in fibromatosis and fasciitis, appear less frequently in malignant fibrous histiocytoma and other sarcomas.

    Area of Science:

    • Surgical Pathology
    • Oncology
    • Cell Biology

    Background:

    • Myofibroblasts are key cellular components in various soft tissue lesions.
    • Distinguishing benign from malignant soft tissue neoplasms can be challenging.
    • The role of myofibroblasts in neoplasia requires further clarification.

    Purpose of the Study:

    • To ultrastructurally examine soft tissue sarcomas for the presence and extent of myofibroblasts.
    • To compare myofibroblast populations in sarcomas versus benign conditions like fibromatosis and fasciitis.
    • To investigate the potential diagnostic significance of myofibroblasts in soft tissue lesions.

    Main Methods:

    • Ultrastructural examination of 129 soft tissue sarcomas.
    • Inclusion of 20 cases of fibromatosis and fasciitis as controls.

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  • Comparative analysis of myofibroblast presence and abundance across different lesion types.

    • Main Results:

    • Myofibroblasts were identified in all malignant fibrous histiocytoma and sclerosing liposarcoma cases, but were not the dominant cell type.
    • Lesser frequencies of myofibroblasts were noted in fibrosarcoma, synovial sarcoma, malignant hemangiopericytoma, and neuroblastoma.
    • Fibromatosis and fasciitis lesions were principally composed of myofibroblasts.
    • Myofibroblasts were absent in sarcomas lacking desmoplasia.

    Conclusions:

    • Abundant myofibroblasts strongly suggest a benign proliferative process over malignancy in soft tissue lesions.
    • The presence of myofibroblasts in sarcomas may represent a host response to neoplasia.
    • Ultrastructural identification of myofibroblasts aids in differentiating benign from malignant soft tissue tumors.