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[Rous virus-induced sarcoma study of Macaca mulatta monkeys]
Voprosy Onkologii
|January 1, 1981
Summary
The Carr-Zilber strain of Rous sarcoma virus causes tumors in Macaca mulata monkeys. Antibody responses varied based on tumor outcome, with neutralizing and gs antibodies detected in tested animals.
Area of Science:
- Oncology
- Virology
- Immunology
Context:
- The Carr-Zilber strain of Rous sarcoma virus (CZ-RSV) is a potent oncogenic agent in adult Macaca mulata monkeys.
- Tumor progression in these animals can lead to host death or spontaneous regression.
Purpose:
- To investigate the characteristics of tumor growth in Macaca mulata infected with CZ-RSV.
- To analyze the kinetics of antibody formation in relation to tumor outcome (regression vs. progression).
Summary:
- This study monitored antibody production against CZ-RSV antigens in monkeys experiencing different tumor trajectories.
- The presence of both virus-neutralizing antibodies and group-specific (gs) antibodies was observed in the sera of the animals.
- Antibody kinetics correlated with whether tumors regressed or progressed to fatal outcomes.
Impact:
- Provides insights into the host immune response to oncogenic retroviruses in a primate model.
- Contributes to understanding the immunological factors influencing tumor regression or progression.
- Informs potential therapeutic strategies targeting viral oncogenesis in non-human primates.