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Topical antibiotics and minor skin trauma

J J Leyden, M B Sulzberger

    American Family Physician
    |January 1, 1981
    PubMed

    Insights

    Topical antibiotic combinations containing neomycin, bacitracin, and polymyxin effectively prevent bacterial infections in minor skin injuries. These antibiotic preparations are safe for general use, with rare side effects and minimal risk of resistance development.

    Area of Science:

    • Dermatology
    • Infectious Diseases
    • Microbiology

    Background:

    • Minor skin trauma presents a risk for bacterial infections.
    • Staphylococcal and streptococcal species are common pathogens in skin infections.

    Purpose of the Study:

    • To evaluate the efficacy and safety of topical neomycin-bacitracin-polymyxin preparations.
    • To assess the incidence of infection and adverse effects associated with topical antibiotic use.

    Main Methods:

    • Double-blind controlled studies were conducted.
    • The application of a neomycin-bacitracin-polymyxin preparation was investigated.

    Main Results:

    • The topical antibiotic preparation significantly reduced the incidence of staphylococcal and streptococcal infections.
    • Allergic sensitization to neomycin was rare.
    • Systemic side effects were observed only with improper, massive exposure.
    • Resistant bacterial strains emerged solely within "closed populations."

    Conclusions:

    • Topical antibiotic combinations are safe and effective for preventing infections in minor skin trauma.
    • The benefits of topical antibiotics outweigh the risks for most patients.
    • Judicious use is recommended to minimize potential for resistance.

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