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Related Experiment Videos

Endogenous hyperinsulinism.

D L Fowler, W G Wood, P G Koontz

    The American Journal of Gastroenterology
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing endogenous hyperinsulinism, a condition causing hypoglycemia due to excess insulin, can be delayed. This review highlights nine cases of organic hyperinsulinism diagnosed between 1965 and 1979.

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    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Surgical Pathology

    Background:

    • Endogenous hyperinsulinism, causing hypoglycemia, has been recognized since the discovery of insulin.
    • Early surgical interventions for insulinomas were reported in 1929, with adenomatosis described in 1944.
    • Whipple's triad remains the classic diagnostic criteria for hyperinsulinism.

    Purpose of the Study:

    • To review clinical cases of organic hyperinsulinism.
    • To highlight diagnostic challenges and delays.
    • To underscore the importance of timely diagnosis and treatment.

    Main Methods:

    • Retrospective review of nine diagnosed cases of organic hyperinsulinism.
    • Analysis of clinical presentations, diagnostic methods, and outcomes.

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  • Utilized serum insulin radioimmunoassay (IRI) for diagnosis.

    • Main Results:

    • Nine cases of organic hyperinsulinism were diagnosed between 1965 and 1979.
    • Despite advancements like IRI, diagnostic delays remain a concern.
    • The study emphasizes the persistent challenges in identifying hyperinsulinism.

    Conclusions:

    • Organic hyperinsulinism requires vigilant diagnosis and management.
    • Timely diagnosis is crucial to prevent severe consequences.
    • This review reinforces the significance of recognizing and addressing hyperinsulinism promptly.